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KMID : 1098420060140030148
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Korean Journal of Medicinal Crop Science
2006 Volume.14 No. 3 p.148 ~ p.152
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Quantitative Analysis of Phenolic Compounds in Different parts of Panax ginseng C.A. Meyer and Its Inhibitory Effect on Melanin Biosynthesis
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Hwang Eun-Young
Choi Sang-Yoon
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Abstract
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Comparison of four phenolic compounds among three different parts of Panax ginseng C.A. Meyer was performed in this study. Contents of esculetin, p-coumaric acd, quercetin, maltol in the ethyl acetate fraction were determinated by HPLC analysis. The main root has a highest concentration of p-coumaric acid and the leave has a highest concentration of quercetin and esculetin. This ethyl acetate fraction of the leaves exhibited higher depigmenting activity and lower cell toxicity than the other parts of ginseng. In addition, it showed that quercetin and esculetin among phenolic compounds highly inhibited melanin biosynthesis in ginseng. It implies that leaves of ginseng may be used as skin whitening herb. Quercetin and esculetin proved to be active compounds in the leaves of ginseng.
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KEYWORD
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Panax ginseng, melanin biosynthesis, quercertin, esculetin
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